Long non-coding RNAs regulation of therapeutic resistance

Cancer Drug Resist. 2019 Sep 19;2(3):550-567. doi: 10.20517/cdr.2019.58. eCollection 2019.

Abstract

Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and cancer stem cell capacity. A subtype of non-protein coding RNA is long non-protein coding RNA (lncRNA). Besides their aforementioned roles in cancer cell biology, dysregulation of lncRNAs contribute to resistance to therapeutic treatments. A couple of important therapeutic classes are chemotherapy and targeted/hormone therapies. This review highlights the variety of malignancies affected by lncRNA dysregulation and the underlying mechanism causing therapeutic resistance.

Keywords: Long non-protein coding RNA; and microRNA sponge; cancer; chemotherapeutic resistance; hormone therapy; target therapeutics.

Publication types

  • Review