ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer

WonSeok William Choi; Julia L Boland; Jianqing Lin

doi:10.20517/cdr.2021.108

ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer

Cancer Drug Resist. 2022 Feb 8;5(1):165-170. doi: 10.20517/cdr.2021.108. eCollection 2022.

Authors

WonSeok William Choi¹, Julia L Boland¹, Jianqing Lin¹

Affiliation

¹ Division of Hematology/Oncology and Department of Medicine, George Washington University Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.

Abstract

Despite androgen dependence in a majority of castration-resistant prostate cancers, some cancer cells are independent of androgen receptor (AR) function, a feature of heterogeneity in prostate cancer. One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer (NEPC). This manuscript will focus on the new finding of human one cut domain family member 2 (ONECUT2) transcription factor and its role in castration resistance, especially in NEPC.

Keywords: ONECUT2; Prostate cancers; androgen receptor-independence; castration resistant; neuroendocrine differentiation.