Reversible regulation of Cas12a activities by AcrVA5-mediated acetylation and CobB-mediated deacetylation

Affiliations

• ¹ CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
• ² University of Chinese Academy of Sciences, Beijing, China.
• ³ Tolo Biotechnology Company Limited, Shanghai, China.
• ⁴ Department of Clinical Laboratory, Shenzhen Second People's Hospital & Institute of Translational Medicine/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
• ⁵ College of Life Sciences, Shanghai Normal University, Shanghai, China.
• ⁶ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China. chenyijian@fudan.edu.cn.
• ⁷ Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China. chenyijian@fudan.edu.cn.
• ⁸ Department of Clinical Laboratory, Shenzhen Second People's Hospital & Institute of Translational Medicine/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China. xuyong_2000@tom.com.
• ⁹ Department of Clinical Laboratory, Shenzhen Second People's Hospital & Institute of Translational Medicine/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China. wangj01@hotmail.com.
• ¹⁰ Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University, Shenzhen, China. wangj01@hotmail.com.