Ultrasound triggered organic mechanoluminescence materials

Adv Drug Deliv Rev. 2022 Jul:186:114343. doi: 10.1016/j.addr.2022.114343. Epub 2022 May 15.

Abstract

Ultrasound induced organic mechanoluminescence materials have become one of the focal topics in wireless light sources since they exhibit high spatiotemporal resolution, biocompatibility and excellent tissue penetration depth. These properties promote great potential in ultrahigh sensitive bioimaging with no background noise and noninvasive nanodevices. Recent advances in chemistry, nanotechnology and biomedical research are revolutionizing ultrasound induced organic mechanoluminescence. Herein, we try to summarize some recent researches in ultrasound induced mechanoluminescence that use various materials design strategies based on the molecular conformational changes and cycloreversion reaction. Practical applications, like noninvasive bioimaging and noninvasive optogenetics, are also presented and prospected.

Keywords: Acoustic cavitation; Bioimaging; Focused ultrasound; Mechanoluminescence; Photocatalysis; ROS; Sonochemistry.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Nanotechnology* / methods
  • Ultrasonography