Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation

Johannes Wild; Julia Ringen; Tabea Bieler; Tanja Knopp; Jérémy Lagrange; Michael Molitor; Katharina Sies; Angela Kropp; Karsten Keller; Andreas Daiber; Thomas Münzel; Manfred Rauh; Ari Waisman; Philip Wenzel; Jens Titze; Susanne Karbach

doi:10.1016/j.jid.2022.04.023

Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation

J Invest Dermatol. 2022 Nov;142(11):3117-3120.e2. doi: 10.1016/j.jid.2022.04.023. Epub 2022 May 14.

Authors

Affiliations

¹ Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany; Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner site Rhein/Main, Frankfurt am Main, Germany.
² Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.
³ Acute and Chronic Cardiovascular Deficiency (Défaillance Cardiovasculaire Aigüe et Chronique), INSERM, Lorraine University, Nancy, France.
⁴ Department of Dermatology, University Heidelberg, Heidelberg, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.
⁶ Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner site Rhein/Main, Frankfurt am Main, Germany.
⁷ Institute for Molecular Medicine Mainz, University Medical Center of Mainz, Mainz, Germany; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
⁸ Programme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore; Division of Nephrology, Duke University School of Medicine, Durham, North Carolina, USA; Division of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.
⁹ Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany; Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner site Rhein/Main, Frankfurt am Main, Germany. Electronic address: karbasu@uni-mainz.de.

PMID: 35580696
DOI: 10.1016/j.jid.2022.04.023

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Estivation
Humans
Imiquimod
Inflammation / drug therapy
Mice
Mice, Inbred BALB C
Psoriasis* / drug therapy
Skin
Skin Diseases*
Water

Substances

Imiquimod
Water