Vapor-Deposited Thin Films: Studying Crystallization and α-relaxation Dynamics of the Molecular Drug Celecoxib

J Phys Chem B. 2022 May 26;126(20):3789-3798. doi: 10.1021/acs.jpcb.2c01284. Epub 2022 May 17.

Abstract

Crystallization is one of the major challenges in using glassy solids for technological applications. Considering pharmaceutical drugs, maintaining a stable amorphous form is highly desirable for improved solubility. Glasses prepared by the physical vapor deposition technique got attention because they possess very high stability, taking thousands of years for an ordinary glass to achieve. In this work, we have investigated the effect of reducing film thickness on the α-relaxation dynamics and crystallization tendency of vapor-deposited films of celecoxib (CXB), a pharmaceutical substance. We have scrutinized its crystallization behavior above and below the glass-transition temperature (Tg). Even though vapor deposition of CXB cannot inhibit crystallization completely, we found a significant decrease in the crystallization rate with decreasing film thickness. Finally, we have observed striking differences in relaxation dynamics of vapor-deposited thin films above the Tg compared to spin-coated counterparts of the same thickness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Celecoxib
  • Crystallization
  • Gases*
  • Glass* / chemistry
  • Pharmaceutical Preparations
  • Transition Temperature

Substances

  • Gases
  • Pharmaceutical Preparations
  • Celecoxib