Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Affiliations

• ¹ Interfaculty Institute of Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.
• ² Clusters of Excellence EXC 2180 "Image-Guided and Functionally Instructed Tumor Therapies" and EXC 2124 "Controlling Microbes to Fight Infection", University of Tübingen, Germany.
• ³ Department of Immunology, Hospital Clinic, Barcelona, Spain.
• ⁴ Department of Immunology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain.
• ⁵ Department of Biochemistry, Molecular Biology and Immunology, Instituto Murciano de Investigación Biosanitaria Arrixaca, Universidad de Murcia, Murcia, Spain.
• ⁶ Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Murcia, Spain.
• ⁷ Pediatric Rheumatology and Autoinflammation Reference Center, Department of Pediatrics I, University Hospital Tübingen, Tübingen, Germany.
• ⁸ Department of Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland.