A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

David A Jamison Jr; S Anand Narayanan; Nídia S Trovão; Joseph W Guarnieri; Michael J Topper; Pedro M Moraes-Vieira; Viktorija Zaksas; Keshav K Singh; Eve Syrkin Wurtele; Afshin Beheshti

doi:10.1038/s41431-022-01108-8

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

Eur J Hum Genet. 2022 Aug;30(8):889-898. doi: 10.1038/s41431-022-01108-8. Epub 2022 May 16.

Authors

David A Jamison Jr^#¹, S Anand Narayanan^#^{2

3}, Nídia S Trovão^{1

4}, Joseph W Guarnieri^{1

5}, Michael J Topper^{1

6}, Pedro M Moraes-Vieira^{1

7

8

9}, Viktorija Zaksas^{1

10}, Keshav K Singh^{1

11}, Eve Syrkin Wurtele^{1

12}, Afshin Beheshti^{13

14

15}

Affiliations

¹ COVID-19 International Research Team, Medford, MA, USA.
² COVID-19 International Research Team, Medford, MA, USA. anarayan09@gmail.com.
³ Department of Nutrition & Integrative Physiology, Florida State University, Tallahassee, FL, USA. anarayan09@gmail.com.
⁴ Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
⁵ Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁶ Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
⁷ Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
⁸ Obesity and Comorbidities research Center (OCRC), University of Campinas, Campinas, SP, Brazil.
⁹ Experimental Medicine Research Cluster, University of Campinas, Campinas, Brazil.
¹⁰ Center for Translational Data Science, University of Chicago, Chicago, IL, USA.
¹¹ Department of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
¹² Center for Metabolic Biology, Bioinformatics and Computational Biology, and Genetics Development, and Cell Biology, Iowa State University, Ames, IA, USA.
¹³ COVID-19 International Research Team, Medford, MA, USA. afshin.beheshti@nasa.gov.
¹⁴ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. afshin.beheshti@nasa.gov.
¹⁵ KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA. afshin.beheshti@nasa.gov.

^# Contributed equally.

Abstract

COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus' mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

COVID-19*
Humans
SARS-CoV-2*
Virus Replication

Grants and funding

P50 CA254897/CA/NCI NIH HHS/United States