Effects of biomimetic hydroxyapatite coatings on osteoimmunomodulation

Jiawei Jiang; Wenbin Liu; Zixuan Xiong; Yihe Hu; Jun Xiao

doi:10.1016/j.msec.2021.112640

Effects of biomimetic hydroxyapatite coatings on osteoimmunomodulation

Biomater Adv. 2022 Mar:134:112640. doi: 10.1016/j.msec.2021.112640. Epub 2022 Jan 8.

Authors

Jiawei Jiang¹, Wenbin Liu², Zixuan Xiong³, Yihe Hu⁴, Jun Xiao⁵

Affiliations

¹ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
² Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Orthopedic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha 410008, China.
³ Department of Orthopedic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha 410008, China.
⁴ Department of Orthopedic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Orthopedic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: csuhuyihe@163.com.
⁵ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: jun_xiao@hust.edu.cn.

PMID: 35577692
DOI: 10.1016/j.msec.2021.112640

Abstract

Macrophages play a very fundamental role in bone regeneration. Changing the physicochemical properties of biomaterials to regulate the genes and protein expressions of Macrophages in vivo is of great significance to promote osteogenesis and angiogenesis in bone tissue engineering. Herein, we investigated the interaction of biomimetic hydroxyapatite coatings with macrophages and the subsequent impact on osteogenesis and angiogenesis. In this study, we found that biomimetic hydroxyapatite coating could inhibit the expression of inflammatory factors (tumor necrosis factor-α, TNF-α) while promoting bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), thereby promoting angiogenesis of vascular endothelial cells and osteogenic differentiation of mesenchymal stem cells. This study demonstrated that biomimetic hydroxyapatite coating modified polycaprolactone (PCL) possessed an excellent osteoimmunomodulatory property and was a promising coating material for the application.

Keywords: Angiogenesis; Bone tissue engineering; Carbonated apatite; Immunomodulation; Polydopamine.

MeSH terms

Biomimetics
Durapatite* / pharmacology
Endothelial Cells / metabolism
Osteogenesis*
Vascular Endothelial Growth Factor A / genetics

Substances

Vascular Endothelial Growth Factor A
Durapatite