Subungual Pigmented Squamous Cell Carcinoma in a Dog

Yeseul Yang; Du-Min Go; Jae-Ha Jung; Dansong Seo; Sung-Hyun Hwang; Mijung Lee; Dae-Yong Kim; Yongbaek Kim

doi:10.1016/j.jcpa.2022.03.010

Subungual Pigmented Squamous Cell Carcinoma in a Dog

J Comp Pathol. 2022 Jun:194:50-53. doi: 10.1016/j.jcpa.2022.03.010. Epub 2022 Apr 27.

Authors

Yeseul Yang¹, Du-Min Go², Jae-Ha Jung³, Dansong Seo¹, Sung-Hyun Hwang¹, Mijung Lee⁴, Dae-Yong Kim⁵, Yongbaek Kim⁶

Affiliations

¹ Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
² Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
³ Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; FOUR Program for Future Veterinary Medicine Leading Education and Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
⁴ Dr Dog Animal Medical Center, Gyeonggi-do, Republic of Korea.
⁵ Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
⁶ Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address: yongbaek@snu.ac.kr.

PMID: 35577459
DOI: 10.1016/j.jcpa.2022.03.010

Abstract

An 11-year-old spayed female Miniature Schnauzer dog was presented with loss of a claw caused by a nail bed mass. Histopathological evaluation revealed that the mass comprised neoplastic squamous cells with abundant cytoplasmic melanin pigment. Immunohistochemically, the neoplastic cells were positive for cytokeratin and negative for vimentin and ionized calcium-binding adaptor molecule 1, supporting a diagnosis of pigmented squamous cell carcinoma. To our knowledge, this is the first report of subungual pigmented squamous cell carcinoma in animals.

Keywords: dog; melanin; pigment; squamous cell carcinoma; subungual.

MeSH terms

Animals
Carcinoma, Squamous Cell* / pathology
Carcinoma, Squamous Cell* / veterinary
Dog Diseases*
Dogs
Female
Keratins
Nail Diseases* / diagnosis
Nail Diseases* / pathology
Nail Diseases* / veterinary
Skin Diseases* / veterinary
Skin Neoplasms* / pathology
Skin Neoplasms* / veterinary

Substances

Keratins