AMPpred-EL: An effective antimicrobial peptide prediction model based on ensemble learning

Abstract

Antimicrobial peptides (AMPs) are important for the human immune system and are currently applied in clinical trials. AMPs have been received much attention for accurate recognition. Recently, several computational methods for identifying AMPs have been proposed. However, existing methods have difficulty in accurately predicting AMPs. In this paper, we propose a novel AMP prediction method called AMPpred-EL based on an ensemble learning strategy. AMPred-EL is constructed based on ensemble learning combined with LightGBM and logistic regression. Experimental results demonstrate that AMPpred-EL outperforms several state-of-the-art methods on the benchmark datasets and then improves the efficiency performance.

Keywords: AMP prediction; Ensemble learning; LightGBM; Logistic regression.