HDL and Lipid Metabolism

Qi Zhang; Yilang Ke; Huashan Hong

doi:10.1007/978-981-19-1592-5_4

HDL and Lipid Metabolism

Adv Exp Med Biol. 2022:1377:49-61. doi: 10.1007/978-981-19-1592-5_4.

Authors

Qi Zhang¹, Yilang Ke², Huashan Hong³

Affiliations

¹ The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.
² Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
³ Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Heart Disease Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. 15959159898@163.com.

PMID: 35575920
DOI: 10.1007/978-981-19-1592-5_4

Abstract

Mediating reverse cholesterol transport (RCT) is the most classic function of HDL. HDL and HDL-C participate in the entire process of RCT, including cholesterol removal from cells, cholesterol transport in circulation, and cholesterol excretion. As cholesterol is a component of lipid rafts and lipid droplets in cells, HDL and RCT can influence cell activity. HDL has also been shown to be related to the metabolism of some other biological lipids, such as S1P and ox-PL. Here we will introduce in detail the molecular mechanism of HDL participation in RCT and its significance.

Keywords: ABCA1; Bile acid; Lipid droplets; Reverse cholesterol transport; S1P; Transintestinal cholesterol excretion.

MeSH terms

Biological Transport
Cholesterol* / metabolism
Cholesterol, HDL / metabolism
Lipid Metabolism*

Substances

Cholesterol, HDL
Cholesterol