Features of the humoral response to immunization "Gam-COVID-Vac" and in patients with COVID-19

Klin Lab Diagn. 2022 Apr 17;67(4):227-233. doi: 10.51620/0869-2084-2022-67-4-227-233.

Abstract

The paper present the results of a survey of people who have undergone immunization with a combined vector vaccine for the prevention of coronavirus infection COVID-19 «Sputnik V - Gam-COVID-Vac», as well as COVID-19 recovalents. Using a quantitative enzyme-linked immunosorbent assay, the levels of specific IgG were determined in persons who had had different degrees of severity before vaccination, in persons who were immuno-negative before immunization, as well as in convalescents who had undergone coronavirus infection of varying severity. The immunological targeting of antibodies against various SARS-CoV-2 proteins is considered.

Keywords: COVID-19; SARS-CoV-2; coronavirus; enzyme-linked immunosorbent assay; immunochromatographic assay.

MeSH terms

  • Antibodies, Viral
  • COVID-19 Vaccines
  • COVID-19* / prevention & control
  • Humans
  • Immunization
  • SARS-CoV-2
  • Vaccination

Substances

  • Antibodies, Viral
  • COVID-19 Vaccines