Persistent trophoblastic atypia on endocervical curettage found to be an epithelioid trophoblastic Tumor: A case report and review of the literature

Allison L Brodsky; Marianne Hom-Tedla; Oluwole Fadare; Michael T McHale

doi:10.1016/j.gore.2022.100994

Persistent trophoblastic atypia on endocervical curettage found to be an epithelioid trophoblastic Tumor: A case report and review of the literature

Gynecol Oncol Rep. 2022 May 5:41:100994. doi: 10.1016/j.gore.2022.100994. eCollection 2022 Jun.

Authors

Allison L Brodsky¹, Marianne Hom-Tedla¹, Oluwole Fadare², Michael T McHale¹

Affiliations

¹ University of California San Diego, Department of Gynecologic Oncology, San Diego, CA, USA.
² University of California San Diego, Department of Pathology, San Diego, CA, USA.

Abstract

We present an unusual case of a 28-year-old female who had atypical trophoblastic proliferation on her endocervical curettage (ECC) performed at the time of a colposcopy. The indication for colposcopy was a Pap smear notable for atypical squamous cells of unknown significance, positive HPV. Initially conservative management was pursued, but given persistent atypia the patient ultimately decided to proceed with definitive management via hysterectomy. Final histologic assessment demonstrated an epithelioid trophoblastic tumor (ETT). This case highlights the unusual scenario of ETT presenting as atypical trophoblastic cells on endocervical curettage and the possible evolution of an atypical placental site nodule into an ETT.

Keywords: Epithelial trophoblastic tumor; Gestational trophoblastic neoplasia.

Publication types

Case Reports