Distributed implantation of a flexible microelectrode array for neural recording

Chunrong Wei; Yang Wang; Weihua Pei; Xinyong Han; Longnian Lin; Zhiduo Liu; Gege Ming; Ruru Chen; Pingping Wu; Xiaowei Yang; Li Zheng; Yijun Wang

doi:10.1038/s41378-022-00366-2

Distributed implantation of a flexible microelectrode array for neural recording

Microsyst Nanoeng. 2022 May 12:8:50. doi: 10.1038/s41378-022-00366-2. eCollection 2022.

Authors

Chunrong Wei^{1

2

3}, Yang Wang^{1

4}, Weihua Pei^{1

2}, Xinyong Han⁵, Longnian Lin⁶, Zhiduo Liu^{1

2}, Gege Ming^{1

2

3}, Ruru Chen⁷, Pingping Wu^{2

3

8}, Xiaowei Yang¹, Li Zheng^{1

2

3}, Yijun Wang^{1

2

9}

Affiliations

¹ State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, 100083 Beijing, China.
² University of Chinese Academy of Sciences, 100049 Beijing, China.
³ School of Future Technologies, University of Chinese Academy of Sciences, 100049 Beijing, China.
⁴ School of Microelectronics, University of Sciences and Technology of China, 230000 Hefei, China.
⁵ Institute of Automation, Chinese Academy of Sciences, 100190 Beijing, China.
⁶ Key Laboratory of Brain Functional Genomics, East China Normal University, 200062 Shanghai, China.
⁷ Brain Machine Fusion Intelligence Institute, 215131 Suzhou, China.
⁸ Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190 Beijing, China.
⁹ Chinese Institute for Brain Research, 102206 Beijing, China.

Abstract

Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions.

Keywords: Electrical and electronic engineering; Other nanotechnology.