CCK2 receptors in chronic pain

Justin E LaVigne; Sascha R A Alles

doi:10.1016/j.ynpai.2022.100092

CCK2 receptors in chronic pain

Neurobiol Pain. 2022 May 5:11:100092. doi: 10.1016/j.ynpai.2022.100092. eCollection 2022 Jan-Jul.

Authors

Justin E LaVigne¹, Sascha R A Alles¹

Affiliation

¹ Dept of Anesthesiology and Critical Care Medicine, University of New Mexico, School of Medicine, Albuquerque, NM 87109, USA.

Abstract

The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In this mini-review, we discuss what is known about CCK2R in peripheral and central circuits under naïve physiological conditions and under conditions of chronic pain, the interactions of CCK2Rs with opioids and briefly, recent efforts to develop new treatments targeting CCK2R for chronic pain.

Keywords: CCK2; Cholecystokinin; Chronic pain; Non-opioid treatment.

Publication types

Review