A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

Longqing Li; Zhuangzhuang Li; Xuanhong He; Yang Wang; Minxun Lu; Taojun Gong; Qing Chang; Jingqi Lin; Yi Luo; Li Min; Yong Zhou; Chongqi Tu

doi:10.3389/fnut.2022.883308

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

Front Nutr. 2022 Apr 28:9:883308. doi: 10.3389/fnut.2022.883308. eCollection 2022.

Authors

Longqing Li^{1

2}, Zhuangzhuang Li^{1

2}, Xuanhong He^{1

2}, Yang Wang^{1

2}, Minxun Lu^{1

2}, Taojun Gong^{1

2}, Qing Chang¹, Jingqi Lin¹, Yi Luo^{1

2}, Li Min^{1

2}, Yong Zhou^{1

2}, Chongqi Tu^{1

2}

Affiliations

¹ Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
² Bone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Osteosarcoma is a primary malignant bone tumor with high metastatic potential. To date, achieving long-term survival of osteosarcoma patients remains a difficult task. Metabolic reprogramming has emerged as a new hallmark of cancer. However, studies on the prognostic value of hematological markers related to nutritional and metabolism in cancer patients are limited and contradictory. In this retrospective study, we extensively collected 16 hematological markers related to nutritional and metabolism in 223 osteosarcoma patients. A nutritional metabolism related prognostic scoring system (NMRS) in patients with osteosarcoma was constructed by least absolute contraction and selection operator (LASSO) cox regression analysis. Compared with individual hematological indicators, NMRS has stronger predictive power (training set: 0.811 vs. 0.362-2.638; validation set: 0.767 vs. 0.333-0.595). It is an independent prognostic factor for the survival of patients with osteosarcoma [HR: 1.957 (1.375-2.786) training set; HR: 3.146 (1.574-6.266) validation set]. NMRS-based nomograms have good and stable predictive power. NMRS facilitates further risk stratification of patients with the same clinical characteristics.

Keywords: hematology; metabolism; nutrition; osteosarcoma; prognosis.