Pan-Cancer Bioinformatics Analysis of Gene UBE2C

Lin Yuan; Zhenyu Yang; Jing Zhao; Tao Sun; Chunyu Hu; Zhen Shen; Guanying Yu

doi:10.3389/fgene.2022.893358

Pan-Cancer Bioinformatics Analysis of Gene UBE2C

Front Genet. 2022 Apr 27:13:893358. doi: 10.3389/fgene.2022.893358. eCollection 2022.

Authors

Lin Yuan¹, Zhenyu Yang¹, Jing Zhao¹, Tao Sun¹, Chunyu Hu¹, Zhen Shen², Guanying Yu³

Affiliations

¹ School of Computer Science and Technology, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
² School of Computer and Software, Nanyang Institute of Technology, Nanyang, China.
³ Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Abstract

Ubiquitin-Conjugating Enzyme E2 C (UBE2C) is a gene that encodes protein. Disorders associated with UBE2C include methotrexate-related lymphatic hyperplasia and complement component 7 deficiency. The encoded protein is necessary for the destruction of mitotic cell cyclins and cell cycle progression, and may be involved in cancer progression. In this paper, on the basis of public databases, we study the expression differential mechanism of gene expression of UBE2C in various tumors and the performance of prognosis, clinical features, immunity, methylation, etc.

Keywords: GSE data; TCGA; gene Expression; immune infiltration; pan-cancer; prognostic analysis.