Graves' Disease after Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in a Type 1 Diabetes Patient

Mayu Sakai; Ken Takao; Takehiro Kato; Kodai Ito; Sodai Kubota; Tokuyuki Hirose; Yanyan Liu; Masami Mizuno; Takuo Hirota; Tetsuya Suwa; Yukio Horikawa; Daisuke Yabe

doi:10.2169/internalmedicine.9231-21

Graves' Disease after Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in a Type 1 Diabetes Patient

Intern Med. 2022;61(10):1561-1565. doi: 10.2169/internalmedicine.9231-21. Epub 2022 May 15.

Authors

Mayu Sakai^{1

2}, Ken Takao^{1

2}, Takehiro Kato^{1

2}, Kodai Ito^{1

2}, Sodai Kubota^{1

2

3}, Tokuyuki Hirose^{1

2}, Yanyan Liu^{1

2}, Masami Mizuno^{1

2}, Takuo Hirota^{1

2}, Tetsuya Suwa^{1

2}, Yukio Horikawa^{1

2}, Daisuke Yabe^{1

2

3

4

5}

Affiliations

¹ Department of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Japan.
² Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan.
³ Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Japan.
⁴ Center for Healthcare Information Technology, Tokai National Higher Education and Research System, Japan.
⁵ Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Japan.

Abstract

Although there is a great demand for increased coronavirus disease 2019 (COVID-19) vaccination worldwide, rare side effects of the vaccine in susceptible individuals are attracting attention. We recently treated a patient with type 1 diabetes who had HLA-A*240201/A*020101, B*5401/B*5601, DRB1*0405/DRB1*0405, DPB1*0501/DPB1*0501 and DQB1*0401/DQB1*040 and developed Graves' disease soon after the administration of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. While causal relationships between vaccinations and adverse events are difficult to discern due to both confounding and masking factors, our findings suggest that attention to possible adjuvant-related endocrinological diseases in certain individuals receiving SARS-CoV-2 vaccines is appropriate.

Keywords: Graves' disease; coronavirus disease 2019; type 1 diabetes; vaccination.

MeSH terms

COVID-19 Vaccines / adverse effects
COVID-19*
Diabetes Mellitus, Type 1* / complications
Graves Disease*
Humans
SARS-CoV-2
Vaccination / adverse effects

Substances

COVID-19 Vaccines