The role of IL-6 in TBI and PTSD, a potential therapeutic target?

Molly Monsour; Davide Marco Croci; Siviero Agazzi

doi:10.1016/j.clineuro.2022.107280

The role of IL-6 in TBI and PTSD, a potential therapeutic target?

Clin Neurol Neurosurg. 2022 Jul:218:107280. doi: 10.1016/j.clineuro.2022.107280. Epub 2022 May 10.

Authors

Molly Monsour¹, Davide Marco Croci², Siviero Agazzi³

Affiliations

¹ University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
² Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA. Electronic address: davidecroci@usf.edu.
³ University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA; Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.

PMID: 35567833
DOI: 10.1016/j.clineuro.2022.107280

Abstract

This literature review focuses on the role of IL-6 in TBI or PTSD-induced neuroinflammation. While TBI and PTSD are widely prevalent, these diagnoses are particularly common amongst veterans. Given the role of IL-6 in neuroprotection acutely, compared to detrimental chronically, targeting this cytokine at specific time points may be beneficial in modulating neuroinflammation. Current treatments for TBI or PTSD are variably affective. By reviewing the role of IL-6 in these two diagnoses, future studies can focus on therapeutics to treat neuroinflammation and ultimately reduce the devastating impacts of neuroinflammation on cognition in PTSD and TBI.

Keywords: Interleukin-6; Posttraumatic stress disorder; Traumatic brain injury.

Publication types

Review

MeSH terms

Brain Injuries, Traumatic*
Humans
Interleukin-6
Stress Disorders, Post-Traumatic* / therapy
Veterans*

Substances

Interleukin-6