A Compositional Analysis of Physical Activity, Sedentary Time, and Sleep and Associated Health Outcomes in Children and Adults with Cystic Fibrosis

Mayara S Bianchim; Melitta A McNarry; Anne Holland; Narelle S Cox; Julianna Dreger; Alan R Barker; Craig A Williams; Sarah Denford; Kelly A Mackintosh

doi:10.3390/ijerph19095155

A Compositional Analysis of Physical Activity, Sedentary Time, and Sleep and Associated Health Outcomes in Children and Adults with Cystic Fibrosis

Int J Environ Res Public Health. 2022 Apr 23;19(9):5155. doi: 10.3390/ijerph19095155.

Authors

Mayara S Bianchim^{1

2}, Melitta A McNarry¹, Anne Holland^{3

4

5}, Narelle S Cox^{3

4}, Julianna Dreger^{3

5}, Alan R Barker⁶, Craig A Williams⁶, Sarah Denford^{6

7}, Kelly A Mackintosh¹

Affiliations

¹ Applied Sports, Technology, Exercise and Medicine Research Centre, Swansea University Bay Campus, Swansea SA1 8EN, UK.
² Nursing, Midwifery and Allied Health Professions Research Unit, University of Stirling, Stirling FK9 4LA, UK.
³ Department of Allergy, Immunology and Respiratory Medicine, Monash University, Melbourne 3004, Australia.
⁴ Alfred Health, Australia Institute for Breathing and Sleep, Melbourne 3004, Australia.
⁵ Alfred Health, Physiotherapy Department, Melbourne 3004, Australia.
⁶ Children's Health and Exercise Research Centre, University of Exeter, Exeter EX1 2LU, UK.
⁷ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK.

Abstract

This study sought to investigate the association of light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), sedentary time (SED), and sleep with lung function in children and adults with CF. In total, 86 children (41 females; 13.6 ± 2.8 years; FEV₁%_predicted: 86 ± 1%) and 43 adults (21 females; 24.6 ± 4.7 years; FEV₁%_predicted: 63 ± 21%) with CF participated in this study. Wrist-worn accelerometery was used to assess PA, SED and sleep. Compositional linear regression models were conducted following normalisation via isometric log-ratio transformations. Sequential binary partitioning was applied to investigate the impact of reallocating 10 to 30 min between each behaviour on FEV₁%_predicted. A decline in FEV₁%_predicted was predicted with the reallocation of 30 min from MVPA to SED or LPA or sleep to any other behaviour in children (-3.04--0.005%) and adults (-3.58--0.005%). Conversely, improvements in FEV₁%_predicted were predicted when 30 min was reallocated to MVPA from LPA or SED in children (0.12-1.59%) and adults (0.77-2.10%), or when 30 min was reallocated to sleep from any other behaviour in both children (0.23-2.56%) and adults (1.08-3.58%). This study supports the importance of MVPA and sleep for maintaining and promoting lung function in people with CF.

Keywords: composition; compositional analysis; lung function; moderate-to-vigorous physical activity; movement behaviours; youth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Accelerometry
Adult
Child
Cystic Fibrosis*
Exercise
Female
Humans
Outcome Assessment, Health Care
Sedentary Behavior*
Sleep