On Collective Molecular Dynamics in Biological Systems: A Review of Our Experimental Observations and Theoretical Modeling

Int J Mol Sci. 2022 May 5;23(9):5145. doi: 10.3390/ijms23095145.

Abstract

We review processes by which different sounds, such as meditation music, mantra, kindness, or hatred expressions, and noises induce responses from cells and their components. We define 'good' or 'bad' sounds as those enhancing or inhibiting the cell's biological activity, respectively. It is highlighted that the cellular dynamics results in a coherent organization with the formation of ordered patterns due to long-range correlations among the system constituents. Due to coherence, in the framework of quantum field theory, extended domains become independent of quantum fluctuations. Non-dissipative energy transfer on macromolecule chains is briefly discussed. Observed fractal features are analyzed by the fast Fourier transform and a linear relationship between logarithms of conjugate variables is observed. The fractal relation to the generation of forms (morphogenesis) and to the transition from form to form (metamorphosis) is commented. The review is also motivated by the suggestions coming from the cells' responses, which show their ability to move from the syntactic level of the sound component frequencies to the semantic level of their collective envelope. The process by which sounds are selected to be good or bad sounds sheds some light on the problem of the construction of languages.

Keywords: cell responses to sounds; cellular contractility; coherent states; fractal and multifractal structures; morphogenesis processes; sounds’ effects on cytoskeleton.

Publication types

  • Review

MeSH terms

  • Energy Transfer
  • Humans
  • Molecular Dynamics Simulation*
  • Noise
  • Quantum Theory*
  • Sound

Grants and funding

This research received no external funding: the entire study was funded by the Department of Cardiac, Thoracic, and Vascular Sciences, and by the Department of Medicine, University of Padua Medical School. Department of Sciences and Technologies, Sannio University, Benevento, Italy, CNR-SPIN Salerno, 84084 Fisciano (Salerno), Italy; Department of Physics “E.R.Caianiello”, Salerno University, 84084 Fisciano (Salerno), Italy.