Substoichiometric action of long noncoding RNAs

Nat Cell Biol. 2022 May;24(5):608-615. doi: 10.1038/s41556-022-00911-1. Epub 2022 May 13.

Abstract

Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs) are often used as evidence for their probable lack of function or for limiting the scope of their potential influence. Recent advances in our understanding of the substoichiometric functions of lncRNAs challenge these notions and suggest routes through which unabundant lncRNAs can affect cellular functions and gene regulatory networks.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Regulatory Networks
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism

Substances

  • RNA, Long Noncoding