Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer

Mingming Yin; Xiaoming Liu; Ziqiao Lei; Yuting Gao; Jiacheng Liu; Sidan Tian; Zhiwen Liang; Ye Wang; Fanling Meng; Liang Luo

doi:10.1038/s41467-022-30263-1

Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer

Nat Commun. 2022 May 12;13(1):2625. doi: 10.1038/s41467-022-30263-1.

Authors

Mingming Yin¹, Xiaoming Liu^{2

3}, Ziqiao Lei^{2

3}, Yuting Gao⁴, Jiacheng Liu^{2

3}, Sidan Tian¹, Zhiwen Liang⁵, Ye Wang⁵, Fanling Meng^{1

6

7}, Liang Luo^{8

9

10}

Affiliations

¹ National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074, Wuhan, China.
² Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
³ Hubei Province Key Laboratory of Molecular Imaging, 430022, Wuhan, China.
⁴ Faculty of Materials Science and Chemistry, China University of Geosciences, 430074, Wuhan, China.
⁵ Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
⁶ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 430074, Wuhan, China.
⁷ Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074, Wuhan, China.
⁸ National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074, Wuhan, China. liangluo@hust.edu.cn.
⁹ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 430074, Wuhan, China. liangluo@hust.edu.cn.
¹⁰ Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074, Wuhan, China. liangluo@hust.edu.cn.

Abstract

X-ray computed tomography (CT) has an important role in precision medicine. However, CT contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention are scarce. Here, poly(diiododiacetylene) (PIDA), a conjugated polymer composed of only carbon and iodine atoms, is reported as an efficient CT contrast agent to bridge CT diagnostic imaging with therapeutic intervention. PIDA has a high iodine payload (>84 wt%), and the aggregation of nanofibrous PIDA can further amplify CT intensity and has improved geometrical and positional stability in vivo. Moreover, with a conjugated backbone, PIDA is in deep blue color, making it dually visible by both CT imaging and the naked eyes. The performance of PIDA in CT-guided preoperative planning and visualization-guided surgery is validated using orthotopic xenograft rat models. In addition, PIDA excels clinical fiducial markers of imaging-guided radiotherapy in efficiency and biocompatibility, and exhibits successful guidance of robotic radiotherapy on Beagles, demonstrating clinical potential to translate CT diagnosis accuracy into therapeutic intervention for precision medicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbon
Dogs
Humans
Iodine*
Phantoms, Imaging
Polymers
Rats
Tomography, X-Ray Computed / methods

Substances

Polymers
Carbon
Iodine