Launching a startup company is like synthesizing a new molecule. There is a starting point and a general concept for how to achieve the desired end. Known steps may be taken, but a successful synthesis is rarely the result of the original plan and relies on perseverance and creativity. If done well, the starting molecule (idea) gives rise to a new final product (business). Having personally lived these journeys, the authors of this viewpoint distilled their combined experiences into relevant topics for scientific entrepreneurs. This viewpoint is not a how-to guide for launching a startup. Instead, relatable personal insights and potential best practices are shared to catalyze discussions around a topic of growing relevance to both the polymer community and workforce of the future.