Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

Daria S Novikova; Tatyana A Grigoreva; Andrey A Zolotarev; Alexander V Garabadzhiu; Vyacheslav G Tribulovich

doi:10.1039/c8ra07576j

Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

RSC Adv. 2018 Oct 10;8(60):34543-34551. doi: 10.1039/c8ra07576j. eCollection 2018 Oct 4.

Authors

Daria S Novikova¹, Tatyana A Grigoreva¹, Andrey A Zolotarev², Alexander V Garabadzhiu¹, Vyacheslav G Tribulovich¹

Affiliations

¹ Laboratory of Molecular Pharmacology, Saint Petersburg State Institute of Technology (Technical University) Moskovskii pr. 26 Saint Petersburg 190013 Russia dc.novikova@gmail.com.
² Department of Crystallography, Saint Petersburg State University per. Dekabristov 16 Saint Petersburg 199155 Russia.

Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.