Targeting HMGA protein inhibits retinoblastoma cell proliferation

Akilandeswari Balachandran; Ajit Zambre; Jagjot Singh Kainth; Lakshmi Dhevi Nagarajha Selvan; Sowmya Parameswaran; Zahra Afrasiabi; Subramanian Krishnakumar; Raghuraman Kannan; Anandhi Upendran

doi:10.1039/c8ra06026f

Targeting HMGA protein inhibits retinoblastoma cell proliferation

RSC Adv. 2018 Sep 7;8(55):31510-31514. doi: 10.1039/c8ra06026f. eCollection 2018 Sep 5.

Authors

Affiliations

¹ Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India drkk@snmail.org drkrishnakumar_2000@yahoo.com.
² Department of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.
³ Department of Life Sciences, Lincoln University Jefferson City MO USA.
⁴ L&T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
⁵ Radheshyam Kanoi Stem Cell Laboratory, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
⁶ Department of Biological Engineering, University of Missouri Columbia MO USA.
⁷ Department of Medical Pharmacology and Physiology, University of Missouri Columbia MO USA.
⁸ Institute of Clinical and Translational Sciences (MU-iCATS), School of Medicine, University of Missouri Columbia MO USA upendrana@health.missouri.edu.

Abstract

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.