Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Luoyang Ma; Xiaoyan Zheng; Rui Lin; Antonia RuJia Sun; Jintong Song; Zhiqiang Ye; Dahong Liang; Min Zhang; Jia Tian; Xin Zhou; Liao Cui; Yuyu Liu; Yanzhi Liu

doi:10.2147/DDDT.S357386

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Drug Des Devel Ther. 2022 May 4:16:1311-1347. doi: 10.2147/DDDT.S357386. eCollection 2022.

Authors

Luoyang Ma^{1

2}, Xiaoyan Zheng^{1

3}, Rui Lin¹, Antonia RuJia Sun⁴, Jintong Song¹, Zhiqiang Ye¹, Dahong Liang¹, Min Zhang¹, Jia Tian¹, Xin Zhou², Liao Cui¹, Yuyu Liu¹, Yanzhi Liu^{1

3

5}

Affiliations

¹ Guangdong Provincial Key Laboratory for Research and Development of Natural Drug, School of Pharmacy, Guangdong Medical University, Zhanjiang City, Guangdong Province, 524023, People's Republic of China.
² Marine Medical Research Institute of Zhanjiang, Zhanjiang City, Guangdong Province, 524023, People's Republic of China.
³ Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang city, Guangdong province, 524045, People's Republic of China.
⁴ Center for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen City, Guangdong Province, 518055, People's Republic of China.
⁵ Shenzhen Osteomore Biotechnology Co., Ltd., Shenzhen city, Guangdong Province, 518118, People's Republic of China.

Abstract

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.

Keywords: drug delivery; intra-articular; knee; osteoarthritis.

Publication types

Review

MeSH terms

Drug Delivery Systems
Humans
Hydrogels
Injections, Intra-Articular
Nanoparticles*
Osteoarthritis, Knee* / drug therapy

Substances

Hydrogels

Grants and funding

This research was funded by grants from the National Natural Science Foundation of China (No. 81703584); The regional joint fund of natural science foundation of Guangdong province (No. 2020B1515120052); Guangdong Province Natural Science Foundation of China (No. 2017A030310614, 2018A030313390, 2016ZC0178, 2021A1515010975); Discipline construction project of Guangdong Medical University (No. 4SG22002G, 4SG21156G); Special Funds for Scientific Technological Innovation of Undergraduates in Guangdong Province (No. pdjh2022a0214); Affiliated Hospital of Guangdong Medical University “Clinical Medicine+” CnTech Co-operation Project (No. CLP2021B012); Guangdong Medical University scientific research fund (No. B2017001); the Fund of Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) (No. ZJW-2019-007).