Reduced graphene oxide-supported methylene blue nanocomposite as a glucose oxidase-mimetic for electrochemical glucose sensing

Shaojun Yang; Daliang Liu; Qing Bo Meng; Shuyao Wu; Xi-Ming Song

doi:10.1039/c8ra06208k

Reduced graphene oxide-supported methylene blue nanocomposite as a glucose oxidase-mimetic for electrochemical glucose sensing

RSC Adv. 2018 Sep 20;8(57):32565-32573. doi: 10.1039/c8ra06208k. eCollection 2018 Sep 18.

Authors

Shaojun Yang¹, Daliang Liu¹, Qing Bo Meng¹, Shuyao Wu¹, Xi-Ming Song¹

Affiliation

¹ Liaoning Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University Shenyang 110036 China sywu@lnu.edu.cn songlab@lnu.edu.cn +86-24-62202378.

Abstract

In this paper, a hybrid nanocomposite (MB-rGO) was synthesized based on the π-π stacking interactions between methylene blue (MB) and reduced graphene oxide (rGO). The as-synthesized nanocomposite was characterized by SEM, TEM, XRD, FTIR, UV-vis and XPS spectra. UV-vis spectroscopy and electrochemical tests suggested the MB-rGO modified on the electrode exhibited glucose oxidase-mimetic catalytic activity towards glucose, and displayed excellent electrocatalytic performance for electrochemical detection of glucose with a wide linear range from 1.04 to 17.44 mM, a low detection limit of 45.8 μM and a large sensitivity of 13.08 μA mM^-1 cm^-2. The proposed glucose sensor also showed high stability, reproducibility and good abilities of anti-interference to dopamine, ascorbic acid and uric acid. Moreover, the modified electrode was used to determine glucose concentration in human blood serum samples with satisfactory results.