Metal-organic frameworks are versatile structures with many different applications, from industry to the clinic. Despite multiple synthesis approaches being able to coordinate metals and organic ligands, some common strategies can be employed when the size of the final product is a target. Here, we review the most relevant examples of synthesized crystals of very large size (i.e., macroscopic, in the scale of mm), emphasizing the critical parameters that impact the final crystal size and quality. This compiled knowledge is intended to be an instructive guide to achieve such crystallizations.