[Nonalcoholic fatty liver disease and liver transplantation]

Zhonghua Gan Zang Bing Za Zhi. 2022 Apr 20;30(4):439-442. doi: 10.3760/cma.j.cn501113-20201022-00574.
[Article in Chinese]

Abstract

The rising prevalence of nonalcoholic fatty liver disease (NAFLD) is now the second largest indication for liver transplantation in Western countries, but viral hepatitis B and end-stage alcohol-related liver disease are still the main indications in China. With the improvement of people's living standards, the prevalence of metabolic syndrome, and the number of NAFLD patients has also gradually increased. At the same time, with the hepatitis B vaccination popularization and the nucleos(t)ide analogues and other drugs uses, it is predicted that NAFLD-related end-stage liver disease may become one of the main indications for liver transplantation in our country in the future. This article reviews the research progress of NAFLD and liver transplantation.

非酒精性脂肪性肝病(NAFLD)患病率日益增高,目前已成为西方国家肝移植的第二大适应证。虽然目前我国肝移植的主要适应证仍是乙型病毒性肝炎以及酒精性肝炎相关终末期肝病,但随着人们生活水平的提高以及代谢综合征的流行,与之相关的NAFLD患者也逐渐增加。同时,随着乙型肝炎疫苗接种的普及以及核苷类似物等药物的应用,可以预见,在未来,NAFLD相关终末期肝病可能会成为我国肝移植的主要适应证之一。现就NAFLD与肝移植的相关研究进展进行综述。.

Publication types

  • Review

MeSH terms

  • End Stage Liver Disease*
  • Humans
  • Liver Transplantation* / adverse effects
  • Metabolic Syndrome*
  • Non-alcoholic Fatty Liver Disease* / epidemiology
  • Prevalence