Areca catechu L. medicinal materials and their preparations are widely used in clinical practice. Betelnut polyphenol is one of the main chemical components with antioxidant, anti-inflammatory, and antibacterial effects. With continuous increase of high altitude activities, tissue oxidative damage caused by high altitude hypoxia seriously affects the ability to work, and the studies on anti-hypoxia drugs are particularly important. Recent studies have shown that betelnut polyphenols have protective effects on oxidative stress injury caused by hypoxia via improving blood gas index of hypoxic organism, increasing superoxide dismutase glutathione catalase activity, and scavenging excessive free radicals. The effects of betelnut polyphenols against hypoxia and oxidative damage protection suggest that betelnut polyphenols can be used as potential anti-hypoxia drugs and posses clinical prospects.
槟榔药材及制剂广泛应用于临床，槟榔多酚为其主要化学成分之一，具有抗氧化、抗炎、抗菌等作用。随着高原活动的不断增加，高原低氧引起的组织氧化损伤严重影响了高原作业能力，因此，抗缺氧药物的研究尤为重要。最新研究表明槟榔多酚通过改善缺氧机体血气指标，提高组织超氧化物歧化酶、谷胱甘肽过氧化氢酶活性，清除机体过多的自由基，对缺氧引起的氧化应激损伤具有保护作用。槟榔多酚的抗缺氧及保护组织氧化损伤的作用提示其可作为潜在的抗缺氧药物，具有一定的开发前景。.
Keywords: anti-hypoxia; antioxidant; betelnut polyphenols; chemical composition.