The role of miRNA-210 in pre-eclampsia development

Ann Med. 2022 Dec;54(1):1350-1356. doi: 10.1080/07853890.2022.2071459.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding, single-stranded RNAs (ribonucleic acids) that play important roles in many vital processes through their impact on gene expression. One such miRNA, miR210, represents a hypoxia-induced cellular miRNA group that hold a variety of functions. This review article highlights the importance of miR-210 in the development of pre-eclampsia.KEY MESSAGEmiR-210 is a promising biomarker for monitoring pregnancy with pre-eclampsia. Overexpression of miR-210 had a negative impact on the process of cell migration and trophoblast invasion.

Keywords: hypoxia; miR-210; pre-eclampsia.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Movement / genetics
  • Female
  • Humans
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Placenta / metabolism
  • Pre-Eclampsia* / genetics
  • Pregnancy
  • Trophoblasts / metabolism

Substances

  • MIRN210 microRNA, human
  • MicroRNAs

Grants and funding

This work was supported by the Medical University of Lublin, Poland, under Grant DS 226.