Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes

Wenhao Dai; Xiaowei Wu; Chunpu Li; Rui Zhang; Jiang Wang; Hong Liu

doi:10.1039/c8ra04083d

Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes

RSC Adv. 2018 Aug 7;8(49):28261-28265. doi: 10.1039/c8ra04083d. eCollection 2018 Aug 2.

Authors

Wenhao Dai^{1

2}, Xiaowei Wu^{2

3}, Chunpu Li², Rui Zhang^{2

3}, Jiang Wang², Hong Liu^{1

2}

Affiliations

¹ School of Pharmacy, China Pharmaceutical University Nanjing 210009 Jiangsu China.
² Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 China hliu@simm.ac.cn.
³ University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China.

Abstract

In this study, ruthenium(ii)-catalyzed direct hydrosilylation of internal alkynes with high regio-selectivity and stereo-selectivity is reported. This title transformation led to various vinylsilanes in good to excellent yields. This approach features mild reaction conditions, low catalyst loading, air-stability, and good functional group tolerance. Furthermore, gram-scale preparation and some transformations of vinylsilanes were carried out, which further underscored its synthetic utility and applicability.