The synthesis of some novel stilbene dimers incorporating diamide tethers: studies in single electron transfer oxidation (FeCl3)

Maryam Sadat Alehashem; Azhar Ariffin; Amjad Ayad Qatran Al-Khdhairawi; Noel F Thomas

doi:10.1039/c7ra12534h

The synthesis of some novel stilbene dimers incorporating diamide tethers: studies in single electron transfer oxidation (FeCl₃)

RSC Adv. 2018 Jan 11;8(5):2506-2520. doi: 10.1039/c7ra12534h. eCollection 2018 Jan 9.

Authors

Maryam Sadat Alehashem¹, Azhar Ariffin¹, Amjad Ayad Qatran Al-Khdhairawi², Noel F Thomas¹

Affiliations

¹ Department of Chemistry, Faculty of Science, University of Malaya 50603 Kuala Lumpur Malaysia maryam.alehashem@yahoo.com azhar70@um.edu.my noelfthomas@um.edu.my noelfthomas@yahoo.com.
² Atta-ur-Rahman Institute for Natural Product Discovery, Faculty of Pharmacy, Universiti Teknologi MARA Selangor Branch 42300 Puncak Alam Selangor Malaysia.

Abstract

The FeCl₃ oxidative cascade reaction of the acetamido stilbene 1 which we reported some years ago produced the first atropodiastereomeric indolostilbene hybrid 3. By contrast, recent investigation of the oxidation of the stilbene succinamide dimer 72 (FeCl₃/CH₂Cl₂) appears, on the basis of spectroscopic evidence, to have produced the bridged macrocyclic indoline 73.