Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

Jingyi Li; Huiyu Hu; Zichao Jiang; Sijie Chen; Yixiao Pan; Qi Guo; Qiqi Xing; Zhaocheng Jing; Yihe Hu; Long Wang

doi:10.1039/c9ra05813c

Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

RSC Adv. 2019 Nov 5;9(62):35976-35983. doi: 10.1039/c9ra05813c. eCollection 2019 Nov 4.

Authors

Jingyi Li¹, Huiyu Hu², Zichao Jiang¹, Sijie Chen³, Yixiao Pan¹, Qi Guo¹, Qiqi Xing¹, Zhaocheng Jing¹, Yihe Hu¹, Long Wang¹

Affiliations

¹ Department of Orthopedics, Xiangya Hospital, Central South University Changsha Hunan 410008 China huyh1964@163.com dr_wanglong@csu.edu.cn +86 13973184558 +86 13974931684.
² Department of General Surgery, Xiangya Hospital, Central South University Changsha Hunan 410008 China.
³ Departmen of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University Changsha Hunan 410011 China.

Abstract

Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in "burning" the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer.