53BP1: guarding the genome with a novel liquid weapon

Naveen Kumar Tangudu; Katherine M Aird

doi:10.1038/s42003-022-03401-0

53BP1: guarding the genome with a novel liquid weapon

Commun Biol. 2022 May 10;5(1):435. doi: 10.1038/s42003-022-03401-0.

Authors

Naveen Kumar Tangudu¹, Katherine M Aird²

Affiliations

¹ Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
² Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. kaa140@pitt.edu.

Abstract

In this Comment, Naveen Tangudu and Katherine Aird discuss recent findings showing that 53BP1 regulates heterochromatin through liquid-liquid phase separation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Genome*

Grants and funding

R37 CA240625/CA/NCI NIH HHS/United States