Discovery and Classification of Glycan-Binding Proteins

Maureen E. Taylor; Kurt Drickamer; Anne Imberty; Yvette van Kooyk; Ronald L. Schnaar; Marilynn E. Etzler; Ajit Varki

doi:10.1101/glycobiology.4e.28

Discovery and Classification of Glycan-Binding Proteins

Review

In: Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 28.

Authors

Maureen E. Taylor, Kurt Drickamer, Anne Imberty, Yvette van Kooyk, Ronald L. Schnaar, Marilynn E. Etzler, Ajit Varki

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Beth Israel Deaconess Medical Center, Director, National Center for Functional Glycomics, Harvard Medical School, Boston, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair, Professor of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
⁵ Sr. Eminent Scholar in Drug Discovery, Georgia Research Alliance William Henry Terry Professor of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁶ Professor of Mycology, ETH Zürich, Institute of Microbiology, Department of Biology, Zürich, Switzerland
⁷ Distinguished Research Professor, Georgia Athletics Association Professor in Complex Carbohydrate Research, Professor of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Endowed Chair and Professor, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Distinguished Professor of Molecular Sciences, Macquarie University, Sydney, Australia and Principal Research Leader, Institute for Glycomics, Griffith University, Gold Coast, Australia
¹⁰ Professor and Eminent Scholar Emeritus, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director of Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany, Professor, Freie Universität, Berlin, Germany

PMID: 35536955
Bookshelf ID: NBK579947
DOI: 10.1101/glycobiology.4e.28

Excerpt

This chapter provides an overview of naturally occurring glycan-binding proteins (GBPs), the history of their discovery, some of their biological functions, ways in which GBPs are identified, and challenges in defining their biologically relevant ligands. The chapters that follow describe the analysis of glycan–protein interactions (Chapter 29), the physical principles involved (Chapter 30), and the structures and biological functions of important subclasses of GBPs (Chapters 31–38).

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