Inflammatory myofibroblastic tumour of the larynx: report of a case

Andrea Colizza; Piero Giuseppe Meliante; Samantha Donsante; Mara Riminucci; Antonio Greco; Marco De Vincentiis; Alessandro Corsi

doi:10.1177/01455613221101087

Inflammatory myofibroblastic tumour of the larynx: report of a case

Ear Nose Throat J. 2022 May 9:1455613221101087. doi: 10.1177/01455613221101087. Online ahead of print.

Authors

Andrea Colizza¹, Piero Giuseppe Meliante¹, Samantha Donsante², Mara Riminucci², Antonio Greco¹, Marco De Vincentiis¹, Alessandro Corsi²

Affiliations

¹ Department of Sense Organs, 9311Sapienza University of Rome, Italy.
² Department of Molecular Medicine, 9311Sapienza University of Rome, Italy.

PMID: 35533742
DOI: 10.1177/01455613221101087

Abstract

Only 0.3-1% of laryngeal cancer are non-squamous cell neoplasms. Of these, a rare entity is inflammatory myofibroblastic tumour (IMT), in which anaplastic lymphoma kinase-1 (ALK-1) is frequently expressed. Just 50 cases of IMT have been reported. Therefore, many otolaryngologists may be unfamiliar with this type of tumour and be prone to its over- or undertreatment.We report a case of ALK-1-negative IMT treated with transoral endoscopic excision and disease-free 6 months after surgery.

Keywords: Larynx; inflammatory myofibroblastic tumour; laryngeal neoplasms; transoral surgery.