Advances in designing of polymeric micelles for biomedical application in brain related diseases

Jaskiran Kaur; Monica Gulati; Bhupinder Kapoor; Niraj Kumar Jha; Piyush Kumar Gupta; Gaurav Gupta; Dinesh Kumar Chellappan; Hari Prasad Devkota; Parteek Prasher; Md Salahuddin Ansari; Faris F Aba Alkhayl; Mohammed F Arshad; Andrew Morris; Yahya E Choonara; Jon Adams; Kamal Dua; Sachin Kumar Singh

doi:10.1016/j.cbi.2022.109960

Advances in designing of polymeric micelles for biomedical application in brain related diseases

Chem Biol Interact. 2022 Jul 1:361:109960. doi: 10.1016/j.cbi.2022.109960. Epub 2022 May 6.

Authors

Jaskiran Kaur¹, Monica Gulati², Bhupinder Kapoor¹, Niraj Kumar Jha³, Piyush Kumar Gupta⁴, Gaurav Gupta⁵, Dinesh Kumar Chellappan⁶, Hari Prasad Devkota⁷, Parteek Prasher⁸, Md Salahuddin Ansari⁹, Faris F Aba Alkhayl¹⁰, Mohammed F Arshad¹¹, Andrew Morris¹², Yahya E Choonara¹³, Jon Adams¹⁴, Kamal Dua¹⁵, Sachin Kumar Singh¹⁶

Affiliations

¹ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
³ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India.
⁴ Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32 - 34, Knowledge Park III, Greater Noida, 201310, Uttar Pradesh, India; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun 248002, Uttarakhand, India.
⁵ School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
⁶ Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
⁷ Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oehonmachi, Kumamoto, 862-0973, Japan.
⁸ Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, 248007, India.
⁹ Department of Pharmacy Practice, College of Pharmacy, Shaqra University, Aldawadmi, Saudi Arabia.
¹⁰ Department of Pharmaceutical Chemistry and Pharmacognosy, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Saudi Arabia; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
¹¹ Department of Research and Scientific Communications, Isthmus Research and Publishing House, New Delhi, 110044, India.
¹² Swansea University Medical School, Room 262, 1st Floor, Grove Building, Swansea University, Singleton Park, Swansea, Wales, SA2 8PP, UK.
¹³ Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa.
¹⁴ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
¹⁵ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
¹⁶ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia. Electronic address: singhsachin23@gmail.com.

PMID: 35533733
DOI: 10.1016/j.cbi.2022.109960

Abstract

In recent years, unique physicochemical properties of amphiphilic block copolymers have been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins, peptides and genes. Their unique properties such as nano-size, charge-switching ability, stimuli-responsive cargo release, flexible structure, and self-assembly enable them to overcome limitations of conventional dosage forms that include rapid drug release, drug efflux, and poor brain bioavailability, and poor stability. These limitations hinder their therapeutic efficacy in treating brain diseases. Their ease of functionalization and enhanced penetration and retention effect make them suitable nanocarriers for the diagnosis of various brain diseases. In this context, the present manuscript provides an insight into the progress made in the functionalization of micelles such as the incorporation of stimuli-sensitive moieties in copolymers, conjugation of cargo molecules with the core-forming block via responsive smart linkers, and conjugation of active ligands and imaging moieties with the corona forming block for brain targeting and imaging. Further, the review also expounds on the role of polymeric micelles in delivering neurotherapeutic to the brain. Some patents related to polymeric micelles formulated for brain delivery are also enlisted.

Keywords: Amphiphilic polymers; Brain targeting; Functionalization; Polymeric micelles.

Publication types

Review

MeSH terms

Brain
Brain Diseases* / drug therapy
Drug Carriers / chemistry
Drug Delivery Systems / methods
Humans
Micelles*
Polymers / chemistry

Substances

Drug Carriers
Micelles
Polymers