New cycloartane coronalyl acetate and other terpenoids with anti-inflammatory activity from the leaves of Vietnamese Gardenia philastrei

Nguyen Khac Hung; Dang Ngoc Quang; Le Dang Quang; Tran Thi Minh; Ta Ngoc Dung; Pham Quang Duong; Nguyen Huu Tung; Vu Dinh Hoang

doi:10.1080/14786419.2022.2074004

New cycloartane coronalyl acetate and other terpenoids with anti-inflammatory activity from the leaves of Vietnamese Gardenia philastrei

Nat Prod Res. 2023 Oct-Nov;37(19):3363-3367. doi: 10.1080/14786419.2022.2074004. Epub 2022 May 9.

Authors

Nguyen Khac Hung^{1

2}, Dang Ngoc Quang³, Le Dang Quang⁴, Tran Thi Minh², Ta Ngoc Dung², Pham Quang Duong¹, Nguyen Huu Tung⁵, Vu Dinh Hoang²

Affiliations

¹ Center For High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
² School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam.
³ Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
⁴ Institute for Tropical Technology (VAST), Hanoi, Vietnam.
⁵ Faculty of Pharmacy, PHENIKAA University, Hanoi, Vietnam.

PMID: 35532362
DOI: 10.1080/14786419.2022.2074004

Abstract

Phytochemical study on the methanolic extract of the leaves of Vietnamese plant Gardenia philastrei Pierre ex Pit. has led to the isolation of a new cycloartane coronalyl acetate (1) together with six known ones, coronlolide methyl ester (2), sootepin D (3), coronalolide (4), coronalolic acid (5), sootepin G (6) and 23-deoxojessic acid (7). Their structures were elucidated by a combination of 2 D NMR and HR-ESI-MS spectroscopies. These compounds (1-7) were tested for their anti-inflammatory activity. The result showed that six compounds (1-6) inhibit LPS-induced nitric oxide production in RAW264.7 macrophages with their IC₅₀ values ranging from 3.76 - 75.47 µg/mL. This is the first report on the chemical constituents and anti-inflammatory activity of the G. philastrei.

Keywords: Gardenia philastrei; anti-inflammatory activity; cycloartane.