Iron phosphide nanoparticles as a pH-responsive T 1 contrast agent for magnetic resonance tumor imaging

Yuan Qiu; Weiwen Lin; Lili Wang; Rui Liu; Jiangao Xie; Xin Chen; Feifei Yang; Guoming Huang; Huanghao Yang

doi:10.1039/c9ra06886d

Iron phosphide nanoparticles as a pH-responsive T ₁ contrast agent for magnetic resonance tumor imaging

RSC Adv. 2019 Sep 26;9(52):30581-30584. doi: 10.1039/c9ra06886d. eCollection 2019 Sep 23.

Authors

Yuan Qiu¹, Weiwen Lin², Lili Wang², Rui Liu¹, Jiangao Xie², Xin Chen¹, Feifei Yang¹, Guoming Huang¹, Huanghao Yang³

Affiliations

¹ College of Biological Science and Engineering, Fuzhou University Fuzhou 350116 P. R. China gmhuang@fzu.edu.cn.
² Department of Diagnostic Radiology, Union Hospital, Fujian Medical University Fuzhou 350001 P. R. China.
³ MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University Fuzhou 350116 P. R. China hhyang@fzu.edu.cn.

Abstract

In this work, the potential of FeP nanoparticles as a pH-responsive T ₁ contrast agent was investigated. The FeP nanoparticles have good biocompatibility and can significantly amplify T ₁ magnetic resonance signals in response to the acidic microenvironment of solid tumors, holding great promise in serving as an acid-activatable T ₁ contrast agent for tumor imaging.