Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications

Doris Ogresta; Anna Mrzljak; Maja Cigrovski Berkovic; Ines Bilic-Curcic; Sanja Stojsavljevic-Shapeski; Lucija Virovic-Jukic

doi:10.14218/JCTH.2021.00268

Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications

J Clin Transl Hepatol. 2022 Apr 28;10(2):339-355. doi: 10.14218/JCTH.2021.00268. Epub 2022 Jan 12.

Authors

Doris Ogresta¹, Anna Mrzljak^{2

3}, Maja Cigrovski Berkovic^{4

5

6}, Ines Bilic-Curcic^{6

7}, Sanja Stojsavljevic-Shapeski¹, Lucija Virovic-Jukic^{1

3}

Affiliations

¹ Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
² Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia.
³ Department of Medicine, University of Zagreb, School of Medicine, Zagreb, Croatia.
⁴ Department for Endocrinology, Diabetes and Pharmacology, University Hospital Dubrava, Zagreb, Croatia.
⁵ Department of Kinesiological Anthropology and Methodology, Faculty of Kinesiology, University of Zagreb.
⁶ Department of Pharmacology, Faculty of Medicine, University of JJ Strossmayer, Osijek, Croatia.
⁷ Department of Diabetes, Endocrinology and Metabolism Disorders, University Hospital Osijek, Osijek, Croatia.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD.

Keywords: Coagulation; Endothelial dysfunction; Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Platelet dysfunction; Thrombosis.

Publication types

Review