Microneedle-Based Device for Biological Analysis

Huiting Lu; Shah Zada; Lingzhi Yang; Haifeng Dong

doi:10.3389/fbioe.2022.851134

Microneedle-Based Device for Biological Analysis

Front Bioeng Biotechnol. 2022 Apr 21:10:851134. doi: 10.3389/fbioe.2022.851134. eCollection 2022.

Authors

Huiting Lu¹, Shah Zada², Lingzhi Yang², Haifeng Dong^{1

2}

Affiliations

¹ Department of Chemistry, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing, China.
² Marshall Laboratory of Biomedical Engineering Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.

Abstract

The collection and analysis of biological samples are an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, the blood sampling approach inevitably relies on invasive techniques and is usually performed by a professional. The microneedle (MN)-based devices have gained increasing attention due to their noninvasive manner compared to the traditional blood-based analysis method. In the present review, we introduce the materials for fabrication of MNs. We categorize MN-based devices based on four classes: MNs for transdermal sampling, biomarker capture, detecting or monitoring analytes, and bio-signal recording. Their design strategies and corresponding application are highlighted and discussed in detail. Finally, future perspectives of MN-based devices are discussed.

Keywords: bio-signal recording; biological analysis; biomarker capture; detection; microneedles; transdermal sampling.

Publication types

Review