Case Report: Co-infection with SARS-CoV-2 and influenza H1N1 in a patient with acute respiratory distress syndrome and a pulmonary sarcoidosis

F1000Res. 2020 Dec 18:9:1482. doi: 10.12688/f1000research.26924.2. eCollection 2020.

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been a global public health concern. We report coinfection of SARS-CoV-2 and 2009 H1N1 Influenza strain in a French patient with pneumonia leading to acute respiratory distress syndrome. The patient also had a medical history of pulmonary sarcoidosis with a restrictive ventilatory syndrome and obesity, which would be a supplementary risk to develop a poor outcomes. This case highlights the possible coinfection of two severe SARS-CoV-2 and influenza H1N1 viruses in comorbid patient, which presents a higher risk to extend the care duration. The overlapping clinical features of the two respiratory syndromes is a challenge, and awareness is required to recommend an early differential diagnosis and it's necessary to adopt the vigilant preventive measures and therapeutic strategies to prevent a deleterious impacts in patients with comorbid factors.

Keywords: Co-infection; Comorbidity; Influenza H1N1; Pulmonary sarcoidosis; SARS-CoV-2.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / complications
  • Coinfection*
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human* / complications
  • Influenza, Human* / diagnosis
  • Respiratory Distress Syndrome* / complications
  • SARS-CoV-2
  • Sarcoidosis, Pulmonary*

Grants and funding

This study was supported by Centre Hospitalier Régional d’Orléans (CHRO).