Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD)

Stem Cell Res. 2022 Jul:62:102794. doi: 10.1016/j.scr.2022.102794. Epub 2022 Apr 27.

Abstract

Becker muscular dystrophy (BMD), an X-linked recessive disorder caused of mutation in the dystrophin gene, is characterized by progressive muscle degeneration and proximal muscle weakness. We generated a human induced pluripotent stem cell (hiPSC) line from the fibroblasts isolated from patient with BMD by non-integrating reprogramming methods. The iPSC line highly expresses pluripotency markers, displays the normal karyotype and is able to differentiate into the three germ layers in vitro. The iPSC line will be a useful tool to study the pathogenesis of BMD and for drug screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fibroblasts / pathology
  • Humans
  • Induced Pluripotent Stem Cells* / metabolism
  • Muscular Dystrophy, Duchenne* / pathology
  • Mutation