Tau Aggregation

Félix Hernández; Isidro Ferrer; Mar Pérez; Juan Carlos Zabala; Jose Antonio Del Rio; Jesús Avila

doi:10.1016/j.neuroscience.2022.04.024

Tau Aggregation

Neuroscience. 2023 May 10:518:64-69. doi: 10.1016/j.neuroscience.2022.04.024. Epub 2022 May 4.

Authors

Félix Hernández¹, Isidro Ferrer², Mar Pérez³, Juan Carlos Zabala⁴, Jose Antonio Del Rio⁵, Jesús Avila⁶

Affiliations

¹ Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain.
² Department of Pathology and Experimental Therapeutics, University of Barcelona, Bellvitge, University Hospital-IDIBELL, Hospitalet de Llobregat, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
³ Departamento de Anatomía Histología y Neurociencia, Facultad de Medicina UAM, Madrid, Spain.
⁴ Department of Molecular Biology, Facultad de Medicina, Universidad de Cantabria, Santander 39005 Spain.
⁵ Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain; Institute of Neuroscience, University of Barcelona, 08028 Barcelona, Spain.
⁶ Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain. Electronic address: javila@cbm.csic.es.

PMID: 35525497
DOI: 10.1016/j.neuroscience.2022.04.024

Abstract

Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. In addition, the presence of non-aggregated tau protein, which has been recently discovered, is also commented on.

Keywords: microtubule-binding repeats; tau; tau conformations; w-tau isoform.

Publication types

Review

MeSH terms

Microtubules* / metabolism
tau Proteins* / metabolism

Substances

tau Proteins