Synthetic nonlinear computation for genetic circuit design

Abstract

Computation frameworks have been studied in synthetic biology to achieve biosignals integration and processing, for biosensing and therapeutics applications. Biological systems exhibit nonlinearity across scales from the molecular level, to biochemical network and intercellular systems. At the molecular level, cooperative bindings contribute to nonlinear molecular signal processing in a way similar to weight variables. At the intracellular network level, feedback and feedforward regulations result in cell behaviors such as multistability and adaptation. When biochemical networks are distributed in different cell groups, intercelluar networks can generate population dynamics. Here, we review works that highlight nonlinear computations in synthetic biology. We group the works according to the scale of implementations, from the cis-transcription level, to biochemical circuit level and cellular networks.