A cannabidiol-containing alginate based hydrogel as novel multifunctional wound dressing for promoting wound healing

Zhe Zheng; Jianchao Qi; Liqiu Hu; Dongfang Ouyang; Huizhen Wang; Qili Sun; Lijun Lin; Lidan You; Bin Tang

doi:10.1016/j.msec.2021.112560

A cannabidiol-containing alginate based hydrogel as novel multifunctional wound dressing for promoting wound healing

Biomater Adv. 2022 Mar:134:112560. doi: 10.1016/j.msec.2021.112560. Epub 2021 Nov 24.

Authors

Zhe Zheng¹, Jianchao Qi², Liqiu Hu¹, Dongfang Ouyang³, Huizhen Wang¹, Qili Sun¹, Lijun Lin⁴, Lidan You⁵, Bin Tang⁶

Affiliations

¹ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China.
² Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China; Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China; Department of Emergency surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, PR China.
³ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
⁴ Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.
⁵ Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
⁶ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China; Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, PR China; Shenzhen Key Laboratory of Cell Microenvironment, PR China. Electronic address: tangb@sustc.edu.cn.

PMID: 35523648
DOI: 10.1016/j.msec.2021.112560

Abstract

In addition to preventing infection and promoting angiogenesis, novel hydrogel dressings are highly expected to possess the potential to scavenge reactive oxygen species (ROS) and reduce inflammatory responses during the wound healing process. In this study, we designed and fabricated a hydrogel dressing (CBD/Alg@Zn) containing cannabidiol (CBD) based on the ion crosslinked interaction between Zn²⁺ ions and the alginate polymer (Alg). The as-fabricated hydrogel exhibited a suitable swelling ratio, sufficient thermal stability, and stable rheological property. In vitro biological activity experiments indicated that the hydrogel has good biocompatibility, antibacterial activity, and angiogenesis properties. Moreover, it could significantly scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals and reduce the inflammatory response. In vivo studies revealed that the CBD/Alg@Zn hydrogel significantly facilitated the wound healing process by controlling the inflammatory infiltration, promoting collagen deposition and the granulation tissue, and benefiting the formation of blood vessels. We, therefore, suggested that CBD/Alg@Zn hydrogel should be a potential candidate material for wound dressing and skin tissue engineering.

Keywords: Alginate; Anti-inflammation property; Antioxidant effect; Cannabidiol; Hydrogel dressing; Wound healing.

MeSH terms

Alginates* / chemistry
Bandages
Cannabidiol* / pharmacology
Hydrogels / pharmacology
Ions
Wound Healing

Substances

Alginates
Hydrogels
Ions
Cannabidiol