Nuclear factor programming improves stem-cell-derived hepatocyte phenotype

Hassan Rashidi; David C Hay

doi:10.1016/j.stem.2022.04.009

Nuclear factor programming improves stem-cell-derived hepatocyte phenotype

Cell Stem Cell. 2022 May 5;29(5):657-658. doi: 10.1016/j.stem.2022.04.009.

Authors

Hassan Rashidi¹, David C Hay²

Affiliations

¹ UCL Great Ormond Street Institute of Child, London, UK; UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
² Institute for Regeneration and Repair, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK. Electronic address: davehay@talktalk.net.

PMID: 35523133
DOI: 10.1016/j.stem.2022.04.009

Abstract

In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.

Publication types

Comment

MeSH terms

Cell Differentiation / genetics
Hepatocytes
Induced Pluripotent Stem Cells*
Phenotype
Pluripotent Stem Cells*

Grants and funding

MR/R015635/1/MRC_/Medical Research Council/United Kingdom